The mutagenic activity of razoxane (ICRF 159): An anticancer agent
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چکیده
منابع مشابه
Bioassay of ICRF-159 for possible carcinogenicity.
A bioassay of the experimental anticancer drug ICRF-159 for possible carcinogenicity was conducted by administering the compound by intraperitoneal injection to Sprague-Dawley rats and B6C3F1 mice. Groups of 35 rats and 35 mice were injected three times per week with ICRF-159 in buffered saline at one of the following doses, either 48 or 96 mg/kg body weight for the rats and either 40 or 80 mg/...
متن کاملDNA topoisomerase II is the molecular target of bisdioxopiperazine derivatives ICRF-159 and ICRF-193 in Saccharomyces cerevisiae.
Bisdioxopiperazines such as ICRF-159 and ICRF-193 have been shown to inhibit DNA topoisomerase II. To determine the molecular target of these compounds in vivo, we utilized a yeast genetic system in which the topoisomerase II activity can be modulated. To reduce topoisomerase II activity, we used top2-1 mutant yeast cells that have normal DNA topoisomerase II activity at 25 degrees C but greatl...
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heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولNasal toxicity and dosimetry of inhaled xenobiotics: implications for human health.
-The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive. Direct measurements of tumour and s.c. oxygen concentrations and...
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arthritic patient. In both experiments the difference between the means is significant by Student’s t test ( P < 0.005), suggesting a decreased reactivity of lymphocytes from rheumatoid-arthritic patients t o phytohaemagglutinin compared with healthy controls. Preliminary experiments with control lymphocytes stimulated with protein A indicated that the optimum concentration of this mitogen was ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1985
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1985.250